Natural-Like Compounds

Synthesis Of Natural Product-like Compounds


Our recent publications:

1. M. S. Frasinyuk and V. P. Khilya, Preparation and reactions of isoflavone heteroanalogs (a review), 1999, Chemistry of Heterocyclic Compounds, V. 35, № 1, p. 3-22.

2. V. S. Moskvina, Ya. L. Garazd, M. M. Garazd, A. V. Turov and V. P. Khilya, Synthesis and structure of 4-arylspirodihydro-pyranochromen-2-one derivatives, 2007, Chemistry of Heterocyclic Compounds, V. 43, № 4, p. 421-429.

3. I. P. Dubovik, M. M. Garazd and V. P. Khilya, 4,4'-Spirodichroman-2-ones as unexpected products from the condensation of resorcinols and dimethyl acetonedicarboxylate, 2007, Chemistry of Heterocyclic Compounds, V. 43, № 3, p. 277-281.

4. S. P. Bondarenko, M. S. Frasinyuk and V. P. Khilya, Reaction of natural isoflavonoids and their analogs with hydroxylamine, 2007, Chemistry of Natural Compounds, V. 43, № 4, p. 402-407.

5. M. M. Garazd, O. V. Muzychka, A. I. Vovk, I. V. Nagorichna and A. S. Ogorodniichuk, Modified coumarins. 27. Ssynthesis and antioxidant activity of 3-substituted 5,7-dihydroxy-4-methylcoumarins, 2007, Chemistry of Natural Compounds, V. 43, № 1, p. 19-23.

6. I. V. Nagorichna, M. M. Garazd, Ya. L. Garazd and V. P. Khilya, Modified coumarins. 26. Synthesis of angular dihydrooxazinocoumarins from 3-hydroxy[ b,d ]pyran-6-one, 2007, Chemistry of Natural Compounds, V. 43, № 1, p. 15-18.

7. M. S. Frasinyuk, S. P. Bondarenko and V. P. Khilya, Reaction of analogs of natural isoflavonoids with amidines, 2006, Chemistry of Natural Compounds, V. 42, № 6, p. 673-676.

8. Ya. L. Garazd, M. M. Garazd, A. S. Ogorodniichuk and V. P. Khilya, Modified coumarins. 24. Synthesis of cycloheptane-annellated tetracyclic furocoumarins, 2006, Chemistry of Natural Compounds, V. 42, № 6, p. 656-664.

9. Ya. L. Garazd, M. M. Garazd, V. A. Turov and V. P. Khilya, Modified coumarins. 23. Synthesis and structure of cyclohexyldihydroxanthyletin derivatives, 2006, Chemistry of Natural Compounds, V. 42, № 6, p. 652-655.

10. M. S. Frasinyuk, S. P. Bondarenko and V. P. Khilya, Synthesis of analogs of natural 2'-methoxyisoflavones, 2006, Chemistry of Natural Compounds, V. 42, № 2, p. 142-147.

11. Ya. L. Garazd, M. M. Garazd and V. P. Khilya, Modified Coumarins. 19. Synthesis of Neoflavone D-Glycopyranosides, 2005, Chemistry of Natural Compounds, V. 41, № 6, p. 663-668.

12. O. V. Khilya, O. V. Shablykina, M. S. Frasinyuk, V. V. Ishchenko and V. P. Khilya, 3-(2-Pyridyl)coumarins, 2005, Chemistry of Natural Compounds, V. 41, № 5, p. 523-528.

13. Ya. L. Garazd, E. M. Kornienko, L. N. Maloshtan, M. M. Garazd and V. P. Khilya, Modified Coumarins. 17. Synthesis and Anticoagulant Activity of 3,4-Cycloannelated Coumarin D-Glycopyranosides, 2005, Chemistry of Natural Compounds, V. 41, № 5, p. 508-512.

14. Ya. L. Garazd, M. M. Garazd and V. P. Khilya, Modified Coumarins. 16. Cyclohexane-Annelated Analogs of Pyranocoumarins, 2005, Chemistry of Natural Compounds, V. 41, № 4, p. 388-395.

15. M. M. Garazd, Ya. L. Garazd, A. S. Ogorodniichuk and V. P. Khilya, Synthesis of Modified Psoralen Analogues, Russian Journal of Bioorganic Chemistry, 2004, V. 30, № 3, p. 291-300.

16. O. V. Khilya, O. V. Shablykina, M. S. Frasinyuk, A V. Turov, V. V. Ishchenko and V. P. Khilya, Chemistry of 3-hetarylcoumarins. 2. 3-(2-Thiazolyl)coumarins, 2004, Chemistry of Heterocyclic Compounds, V. 40, № 11, p. 1408-1420.

17. V. V. Arkhipov, M. M. Garazd, M. N. Smirnov and V. P. Khilya, Chemistry of Modified Flavonoids. 24. Synthesis of 4- Aryloxy-3-(2-hydroxy-4-hydroxy/alkoxyphenyl)pyrazoles, 
2004, Chemistry of Heterocyclic Compounds, V. 40, № 2, p. 183-187.

18. Ya. L. Garazd, M. M. Garazd and V. P. Khilya, Modified coumarins. 15. Condensed psoralen derivatives based on substituted dibenzo[b,d]pyran-6-ones, 2004, Chemistry of Natural Compounds, V. 40, № 6, p. 535-540.

19. I. P. Dubovik, M. M. Garazd and V. P. Khilya, Modified coumarins. 14. Synthesis of 7-hydroxy-[4,3']dichromenyl-2,2'-dione derivatives, 2004, Chemistry of Natural Compounds, V. 40, № 5, p. 434-443.

20. Ya. L. Garazd, M. M. Garazd and V. P. Khilya, Modified coumarins. 13. Synthesis of cyclopentane-annelated pyranocoumarins, 2004, Chemistry of Natural Compounds, V. 40, № 5, p. 427-433.

21. Ya. L. Garazd, M. M. Garazd and V. P. Khilya, Modified Coumarins. 12. Synthesis of 3,4-Cycloannelated Coumarin D-Glucopyranosides, 2004, Chemistry of Natural Compounds, V. 40, № 1, p. 6-12.

22. S. P. Bondarenko, M. S. Frasinyuk and V. P. Khilya, Synthesis of 3',4'-Dimethoxyisoflavone Derivaties, 2003, Chemistry of Natural Compounds, V. 39, № 4, p. 340-343.

23. Ya. L. Garazd, T. N. Panteleimonova, M. M. Garazd and V. P. Khilya, Modified Coumarins. 11. Synthesis and Biological Activity of Mannich Bases of Substituted 1,3-Dihydrocyclopenta[c]chromen-4-ones, 2003, Chemistry of Natural Compounds, V. 39, № 4, p. 330-336.

24. S. P. Bondarenko, A. V. Levenets, M. S. Frasinyuk and V. P. Khilya, Synthesis of Analogs of Natural Isoflavonoids Containing Phloroglucinol, 2003, Chemistry of Natural Compounds, V. 39, № 3, p. 271-275.

25. S. P. Bondarenko, M. S. Frasinyuk and V. P. Khilya, Synthesis of Pseudobaptigenin Analogs, 2003, Chemistry of Natural Compounds, V. 39, № 3, p. 265-270.

26. I. V. Nagorichna, I. P. Dubovik, M. M. Garazd and V. P. Khilya, Modified Coumarins. 10. Synthesis of Substituted 2-(7-Oxofuro[3,2-g]chromen-6-yl)acetic Acids, 2003, Chemistry of Natural Compounds, V. 39, № 3, p. 253-261.

27. M. M. Garazd, Ya. L. Garazd, A. S. Ogorodniichuk and V. P. Khilya, Modified Coumarins. 8. Synthesis of Substituted 5-(4-Methoxyphenyl)-7H-furo[3,2-g]chromen-7-ones, 
2002, Chemistry of Natural Compounds, V. 38, № 6, p. 539-548.

28.Ya. L. Garazd, T. N. Panteleimonova, M. M. Garazd and V. P. Khilya, Modified Coumarins. 7. Synthesis and Biological Activity of Mannich Bases of Substituted 7,8,9,10-Tetrahydrobenzo[c]chromen-6-ones, 2002, Chemistry of Natural Compounds, V. 38, № 6, p. 532-538.

29. Ya. L. Garazd, A. S. Ogorodniichuk, M. M. Garazd and V. P. Khilya, Modified Coumarins. 6. Synthesis of Substituted 5,6-Benzopsoralens, 2002, Chemistry of Natural Compounds, V. 38, № 5, p. 424-433.

30. M. M. Garazd, Ya. L. Garazd, S. V. Shilin, T. N. Panteleimonova and V. P. Khilya, Modified Coumarins. 4. Synthesis and Biological Properties of Cyclopentaneannelated Furocoumarins, 
2002, Chemistry of Natural Compounds, V. 38, № 3, p. 230-242.

31. A. E. Zemlyakov, V. O. Kur'yanov, T. A. Chupakhina, V. Ya. Chirva, V. V. Ishchenko, M. M. Garazd and V. P. Khilya, Synthesis of N-Acetylglucosaminides with Coumarin and Chromone Aglycones, 2002, Chemistry of Natural Compounds, V. 38, № 2, p. 149-153.

32. Ya. L. Garazd, M. M. Garazd, S. V. Shilin and V. P. Khilya, Modified Coumarins. 3. Psoralen and allopsoralen analogs,  2001, Chemistry of Natural Compounds, V. 37, № 5, p. 409-420.

33. O. V. Khilya, M. S. Frasinyuk, A. V. Turov and V. P. Khilya, Chemistry of 3-Hetarylcoumarins. 1. 3-(2-Benzazolyl)coumarins, 2001, Chemistry of Heterocyclic Compounds, V. 37, № 8, p. 1029-1037.

34. M. M. Garazd, Ya. L. Garazd, S. V. Shilin and V. P. Khilya, Modified Coumarins. II. Mannich Reaction of Substituted 4-Phenylcoumarins, 2000, Chemistry of Natural Compounds, V. 36, № 5, p. 485-492.

35. M. M. Garazd, Ya. L. Garazd, S. V. Shilin and V. P. Khilya, Modified Coumarins. I. Synthesis of 5-Phenyl-7H-furo[2, 3-g]chromen-7-ones and 9-Phenyl-7H-furo-[2, 3-f]chromen-7-ones, 2000, Chemistry of Natural Compounds, V. 36, № 5, p. 478-484.

36. M. S. Frasinyuk, A. V. Turov and V. P. Khilya, Chemistry of the hetero analogs of isoflavones. 22. Mannich reaction in the benzimidazole and benzothiazole analogs of isoflavones, 1998, Chemistry of Heterocyclic Compounds, V. 34, № 8, p. 923-928.

37. M. M. Garazd, A. S. Ogorodniichuk, V. V. Shilin, S. A. Vasil'ev, A. V. Turov and V. P. Khilya, 5,7-Dihydroxy-3-phenoxychromones: Synthesis and properties, 1998, Chemistry of Natural Compounds, V. 34, № 4, p. 435-441.

38. M. S. Frasinyuk and V. P. Khilya, Chemistry of the heteroanalogs of isoflavones. 21. 1-benzimidazole analogs of isoflavones, 1997, Chemistry of Heterocyclic Compounds, V. 33, № 10, p. 1196-1198.

39. M. S. Frasinyuk, N. V. Gorbulenko and V. P. Khilya, Chemistry of the heteroanalogs of isoflavones. 20. Benzimidazole analogs of isoflavones, 1997, Chemistry of Heterocyclic Compounds, V. 33, № 9, p. 1078-1085.

40. V. P. Khilya, A. Aitmambekov, V. G. Pivovarenko, D. M. Zakharik and Ya. L. Shvachko, Synthetic and modified isoflavonoids. XIII. Synthesis of analogues of fujikinin, 1995, Chemistry of Natural Compounds, V. 30, № 3, p. 316-319.

41. N. V. Gorbulenko, M. S. Frasinyuk and V. P. Khilya, Chemistry of heteroanalogs of isoflavones. 16. Benzthiazole analogs of isoflavones, 1994, Chemistry of Heterocyclic Compounds, V. 30, № 4, p. 405-412.